The Tennessee Titans head to Indianapolis this week for a Week 6 AFC South matchup with the Colts, and one of the bigger injury questions on their side centers on Tyjae Spears.
Spears is listed as questionable with a knee injury after a week that saw his practice status move all over the map. He did, however, finish strong by practicing fully on Friday, which is usually the kind of sign teams like to see heading into Sunday.
Tennessee is dealing with a few other absences as well. Starting safety Kevin Winston Jr. is out with a quad injury, and defensive tackle Jordan Elliott is sidelined for NIR/personal reasons. To help fill those spots, the Titans will elevate safety Isaiah Oliver and defensive tackle Timmy Horne from the practice squad.
As for Spears, the setup points toward him being available. The Titans cannot elevate a running back for this game, and that makes him a strong bet to suit up against a division opponent. Still, Tennessee already has five running backs on the 53-man roster, so inactive status would not be completely off the table.
His Friday return to full participation comes after he missed Thursday’s session, and that movement suggests he’s trending in the right direction for Sunday. If he does play, he could have a meaningful role after leading the backfield in snaps during the Week 5 loss to the Houston Texans.
If Spears can’t go, the most obvious replacement is veteran Michael Carter. He’s already on the active roster, shares a similar skill set, and has been with the team since after the Week 3 game against the New York Giants, though he has not yet been used and has been inactive on game days.
Another possibility is rookie Nick Singleton, who has some game experience in 2026. Singleton was inactive for the Week 5 game against Houston, but he could see more work if Tennessee chooses that route.
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