The 49ers got the win they wanted over Seattle, but the evening came with a familiar, uneasy subplot: Deebo Samuel left with a hamstring injury after a costly fumble and did not return.
San Francisco held on for a 32-29 victory at home in a game that had plenty of chaos packed into it, including a first Brandin Cooks touchdown since he signed with the team. The margin was tight, the turnovers piled up, and one of the night’s most important moments came when Samuel put the ball on the ground before going down with the injury.
Samuel finished with two carries and two receptions for 25 combined yards. His exit added another wrinkle to a game where the 49ers offense was limited to 269 yards. Even so, Kyle Shanahan’s group still outgained Seattle, which finished with 251 yards, and the 49ers came out on top in a turnover-heavy battle: San Francisco had three and the Seahawks had four.
Deebo Samuel fumbled it, went down, and stayed down afterward.
— ClutchPoints (@ClutchPoints) October 11, 2026
He has already been ruled out for the remainder of 49ers-Seahawks with a hamstring injury.pic.twitter.com/2VRQTobFO0
The 49ers leaned on Christian McCaffrey, who led the team with 68 rushing yards. Brock Purdy was under pressure throughout, taking three sacks and throwing one interception, but San Francisco still found enough offense to survive.
There was also a noteworthy performance from Mike Evans, who had been dealing with stabbing pain in his ribs but still came through with seven catches for 113 yards and a touchdown to lead the 49ers.
Dre Greenlaw’s night ended too, though for a different reason, as the linebacker was ejected for a late hit.
At 5-0, the 49ers sit in first place in the NFC West and now turn to a home date with the Commanders on October 19 at Levi’s Stadium. Samuel’s injury lands as the latest setback in a long list of difficult ones, and the team moves forward trying to stay hot while hoping to get healthier.
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The more memorable moment came when Evans got into a brief trash-talking exchange with Seahawks cornerback Trevon Diggs, a scene that made the broadcast rounds and added a little extra edge to an already physical game. Evans later said he did not realize who he was jawing with at first because of the helmet, a small detail that only added to the oddness of a chippy divisional matchup and the buzz surrounding his early impact in San Francisco. [Read more 🡒]