Week 2 of the 2026 NFL preseason opens Thursday night, and the betting card comes with a familiar preseason twist: trying to separate real offensive spark from the long stretches of backup football that can turn a clean read into a mess fast.
There are two games on the slate, and the approach here is simple. One matchup leans on depth and a coaching edge, while the other points more toward points than a side.
The Texans enter after a shaky first week, but DeMeco Ryans has a strong track record as a preseason coach when it comes to covering the spread. The bigger issue for the opponent is what happens once the backups take over.
The Raiders already showed that side of the roster can get ugly, failing to score in the second half against one of the worst rosters in the NFL. Now they’re lining up against a Texans team that is among the league’s best when the starters are on the field.
Mendoza should look good again, but the Texans are expected to take control after halftime.
Even so, the better move in that game is to avoid the spread and play the OVER. With offensive starters expected to get at least a series, both teams have enough talent on that side of the ball to keep the scoring moving.
The other play is in the all-California matchup, where the case is also for offense. The Chargers are coming off a game in which they scored 27 points against a strong Houston Texans defense, and they bring plenty of talent when their starters are out there.
San Francisco didn’t do much offensively in its first preseason game, but that came without Brock Purdy on the sideline and without backup quarterback Mac Jones getting any reps either. With both quarterbacks expected to see action this time, the expectation is that the 49ers will find more room to move the ball and put up points.
So the lean for Thursday is clear: one game where the OVER makes sense because of starter-driven offense, and another where the scoreboard should stay busy in a matchup built for scoring.
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Jacob Cowing, DeZhaun Stribling, Kaelon Black, Carver Willis, Austen Pleasants and Jalen Stroman all saw meaningful action, with the results mixed as the staff sorted through a crowded roster battle. Adrian Martinez handled the second half and left a little bit of everything on the tape, including a pick-six, but also a rushing touchdown and a passing touchdown as the 49ers kept the scoreboard moving while the evaluation window stayed wide open. [Read more 🡒]
49ers Injury Pileup Is Raising New Concerns Before Week 1
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49ers Facing Uncomfortable Roster Calls As Two Camp Battles Intensify
The 49ers are moving deeper into preseason evaluation mode, and a couple of roster questions are starting to feel less like camp chatter and more like decisions the front office may have to live with. Christian McCaffrey remains part of the bigger picture, but the more immediate pressure is on players such as Kirk and Colby, whose place on the roster now depends on how the team weighs performance, health, and fit as August unfolds.
Kirks case has become especially tricky because the injury interruptions have stacked up alongside a dip in production, which puts him in the middle of a real cut conversation rather than a routine depth chart debate. Colby, meanwhile, is fighting a different kind of battle, one centered on the starting guard job and the sort of interior competition Kyle Shanahan and Chris Foerster tend to use as a true test of who can hold up when the pads come on. [Read more 🡒]