The 49ers’ defense had a challenging 2025 season, making life a bit too easy for opposing quarterbacks. With the 2026 NFL Draft approaching, it’s clear that bolstering their pass rush is a top priority, especially with the No. 27 overall pick in their sights.
Last season, the 49ers recorded just 20 sacks, trailing far behind the league-leading Denver Broncos, who racked up 68. To put it in perspective, Myles Garrett of the Cleveland Browns alone notched an NFL-record 23 sacks. It’s evident that the 49ers need a game-changer on their defensive line.
Nick Bosa and Mykel Williams, the team’s projected starting defensive ends, are both on the mend from torn ACLs. Their return is crucial, but the team also faces uncertainty with their depth at defensive end.
Bryce Huff started strong with four sacks in his first seven games but then went cold. Keion White, who joined midseason from New England, is recovering from surgery after a gunshot wound to his ankle.
With the NFL Scouting Combine in full swing, the 49ers are keenly observing the defensive linemen’s workouts in Indianapolis. Holding the 27th pick means they might miss out on top prospects like Arvell Reese and David Bailey, but there are still promising options available.
Akheem Mesidor, Miami
Mesidor brings a wealth of experience, having played six seasons of college football. His final season was stellar, finishing with 12.5 sacks. Though he may not have the prototypical size, his instincts and relentless effort make him a potential top-20 pick.
T.J. Parker, Clemson
Parker didn’t quite replicate his standout 2024 season, but he still impressed scouts. With 11 sacks and six forced fumbles in 2024, and a solid performance at the Senior Bowl, Parker remains a strong candidate.
R Mason Thomas, Oklahoma
Thomas might not be an every-down player, but his potential as a situational pass-rusher is intriguing. His performance in position drills will be crucial in determining his fit at the next level.
Cashius Howell, Texas A&M
Howell is known for his ability to bend around the corner and disrupt quarterbacks, tallying 27 sacks in his college career. While he may lack size for run defense, his pass-rushing skills could shine on critical downs.
Zion Young, Missouri
Young is a versatile defensive end who can slide inside on passing downs. He’s coming off a career-high season with 6.5 sacks and 16.5 tackles for loss. However, a recent legal issue involving a DWI charge could impact his draft stock.
As the 49ers look to reinforce their defense, these prospects offer a mix of experience, skill, and potential to revitalize their pass rush and make a significant impact in the upcoming season.