The middle of the 2026 college football regular season is here, and the target on ranked teams is getting harder to miss.
At least five top-25 teams have gone down in consecutive weeks, which is exactly why this Saturday feels loaded with upset potential. A few of the teams sitting in the rankings are winning, but not exactly convincing anyone along the way.
One of the most intriguing matchups sends Bob Chesney back to Oregon, this time with UCLA. Less than a year ago, Chesney brought an overmatched James Madison group to Eugene for a College Football Playoff game against the Ducks. Oregon won that one 51-34, but James Madison made it a fight and actually outscored the Ducks 28-17 in the second half.
Now Chesney returns with a UCLA team that has already beaten expectations. The Bruins are 4-0 and ranked No. 21, and both of their road wins have come by 21 points or more.
Oregon, meanwhile, bounced back from its early loss to Oklahoma State with a big win over USC, but there’s a catch: star quarterback Dante Moore was injured in that game and may not be able to go Saturday. Even with the hostile setting, UCLA doesn’t look like a team that’s planning to roll over.
Missouri also enters the weekend with momentum after one of the possible upsets from last week came through. The Tigers hammered Florida in Columbia and are coming off a win over a top-10 opponent after a loss to Mississippi State.
Still, there’s a reason they keep showing up in upset conversations. This is the same Missouri team that sleepwalked through a home game against Troy and had to rally from a double-digit deficit.
The flaws are there, and they tend to surface.
Texas A&M gets the next shot at testing that. The Aggies have been underwhelming so far, though the talent is still obvious, and this could be the week Marcel Reed gets something going.
Missouri may also be a little vulnerable to a letdown after such a dominant performance. Replicating that kind of outing back-to-back is never easy.
USC is in familiar territory on this list, too. Lincoln Riley’s team keeps living on the edge, barely surviving Rutgers 42-35 and Washington 25-21 before getting knocked around by Oregon at home.
The Trojans are 5-1, but the defense remains a real issue. Penn State comes in having lost two straight and is somehow the favorite, but USC is still the ranked team here, which makes this an upset spot by definition.
If the Trojans’ defense disappears again, Riley’s seat only gets hotter.
Houston has also been hanging around danger. The Cougars haven’t looked the same since the loss to Texas Tech.
They needed 42 points to get past Georgia Southern by 14 and had to rally from 17-0 down against UCF. Now they’re on the road again, where the challenge gets much tougher.
Kansas State is trying to land the shocker, and while the Wildcats lost last week, they did win all three of their home games by double digits. First-year head coach Collin Klein is still looking for his first signature win.
Pittsburgh closes out the list in what could be one of the ACC’s most interesting games of the weekend. The Panthers survived at Virginia Tech, but they lost starting quarterback Mason Heintschel for the rest of the season in the process.
Holden Geriner, who previously played at Auburn and Texas State, is the veteran option, but his résumé is thin: he has thrown for 334 yards, and 219 of those came in 2026. His first start comes at home, but North Carolina brings a defense that can get creative under Bill Belichick.
The Tar Heels have dropped two straight, and a win over Pittsburgh would be a chance to steady things.
In Other News...
Oregon's Quarterback Crisis Just Got Harder To Ignore
Oregons quarterback situation was already under a bright enough spotlight with Dante Moore sidelined by a concussion, and the fourth quarter against UCLA only sharpened the concerns. After Dylan Raiola struggled with turnovers, Dan Lanning turned to Brock Thomas, a move that underscored how little margin the Ducks had as the offense searched for a rhythm. Even with a touchdown and a field goal on the board, the Ducks were still chasing the game late.
The trouble was not just the score, but the way the offense kept putting itself in difficult spots. Multiple turnovers and other offensive issues left Oregon trailing 17-9 entering the fourth quarter, and the shuffle under center made the depth chart feel unsettled at a moment when stability mattered most. For a team built to compete at the top of the conference, the quarterback conversation is suddenly becoming impossible to ignore. [Read more 🡒]
Oregon Win Now Comes With A Big Ten Question For Bear Alexander
Oregons win over UCLA is already producing a bigger aftershock than the final score, because a viral clip from the game has put defensive tackle Bear Alexander in the middle of a possible Big Ten review. The video appears to show Alexander striking Bruins quarterback Nico Iamaleava during a tackle, and Iamaleava later left with a lower body injury, leaving the play under fresh scrutiny as the conference weighs its next step.
The Big Ten has a sportsmanship policy that can allow for discipline in cases like this, and Oregon is waiting to see whether the league decides to act. The situation also lands in a sensitive spot for Dan Lanning, who recently condemned a similar incident involving another player, making the conferences response to Alexanders case the next development that could shape how the aftermath of the game is remembered. [Read more 🡒]
Oregon Heads To Nebraska With A Quarterback Problem And Bigger Questions
The late push from Brock Thomas gave Oregon something to hang onto after a 17-15 loss to No. 21 UCLA, but it also left the Ducks with a familiar kind of uncertainty as they head to Nebraska. Thomas stepped in for starter Dylan Raiola in the fourth quarter and helped lead scoring drives, yet the bigger picture was hard to ignore: turnovers, penalties and offensive line problems kept the offense from ever finding a steady rhythm, even as the defense did enough to keep the game within reach.
Now the attention shifts to the quarterback picture, and it is not getting any clearer. Oregon could also be waiting on the possible return of Dante Moore from injury, which only adds another layer to a situation already made messy by the loss to UCLA. The Ducks leave with a hard-earned defensive performance to build on, but with the offense still searching for answers, the trip to Nebraska feels like a test of both depth and direction. [Read more 🡒]