Oklahoma State Faces Its Biggest Oregon Problem Before Kickoff

Can Oklahoma State overcome a major injury and historical odds to compete against a formidable Oregon squad?

STILLWATER - Oklahoma State has already absorbed a brutal blow before No. 6 Oregon ever steps on the field in Boone Pickens Stadium.

The Cowboys will try to answer the Ducks on Saturday at 11 a.m. on ESPN without left tackle Jacob Sexton, who is out for the season after suffering a leg injury last week. OSU head coach Eric Morris said the 6-foot-6, 328-pound Sexton has been the team’s best offensive lineman so far, and his absence leaves a major hole on both the physical and mental side of the line.

That was on display in last Saturday’s 24-10 loss at Tulsa, when quarterback Drew Mestemaker was sacked twice and hit with 10 hurries. Center Tyler Mercer said the group didn’t handle the loss of Sexton the way it needed to.

"I would say it's difficult,” OSU center Tyler Mercer said. “I think we didn't handle that very well, quite honestly.

It's definitely in the back of our minds, like, dang, Jacob's down. But I think what we need to do better going forward is realizing that, hey, he is down and adjusting from there and realizing that it can't hold us down.

We still have to perform and protect Drew, let him make plays because he can. But ultimately, it's up to us to give him time to make those plays.”

The assignment gets even tougher against an Oregon front that brings back edge rushers Matayo Uiagalelei and Teitum Tuioti, along with interior linemen A'Mauri Washington and Bear Alexander. The Ducks recorded three sacks last week, and Mercer said Sexton’s injury can be used as fuel.

“Just asking for broader shoulders and realizing that we've gotta take another step, evidently, with this unit coming up this weekend, obviously that's gonna be a challenge,” Mercer said.

The numbers and the matchup both lean heavily toward Oregon. Oklahoma State is 0-2 all-time against the Ducks, with the first loss coming in the 2008 Holiday Bowl, and the Cowboys are a 22.5-point underdog. Saturday also marks the first time a current Big Ten Conference program has played football in Stillwater, even though Nebraska, Washington and UCLA have previously played there.

Our predictions for the game:

Joe Mussatto, columnist: Oregon 38, OSU 14

"SITTING DUCK"

OSU will put up a better fight than last year, but Oregon is the far superior football team. After not banking a win at Tulsa, OSU seems destined for an 0-2 start.

Jenni Carlson, columnist: Oregon 41, OSU 17

"DUCK AND COVER"

The Cowboys show signs of improvement after their loss to Tulsa, but the Ducks are too good for that to matter in the final score. OSU and Eric Morris have an uphill climb on their hands.

Jeff Patterson, sports editor: Oregon 41, OSU 28

"QUACKTASTIC"

Drew Mestemaker and the Cowboys put up a fight in their home opener, but coach Dan Lanning's Ducks are a national title contender for a reason.

Jacob Unruh, deputy sports editor: Oregon 40, OSU 24

"QUACKED UP"

The Cowboys will show more life, particularly on offense with Drew Mestemaker looking closer to the 2025 version that brought tons of hype. But the Pokes' defense has no answer for Dante Moore and the plethora of talent around him.

Ben Hutchens, OSU beat writer: Oregon 44, OSU 18

"MOORE OF THE SAME"

Oregon quarterback Dante Moore has a big passing day as the Ducks comfortably defeat Cowboys for second straight year. Against strong Oregon defense and without tackle Jacob Sexton, OSU offense still looks like its coming together.

In Other News...

Kansas Enters A Program Defining Test With One Huge Offensive Question

Week 2 of the 2026 Big 12 season brings a few early tone-setters, and Oklahoma State is already staring at a matchup that says plenty about where things stand. After an opening loss that exposed how hard it has been to get the offense moving, the Cowboys now turn to a home date with Oregon, a game that should stretch every part of the roster and force a quick answer on whether the unit can find a rhythm.

The odds tell the story as clearly as anything else, with Oklahoma State lined as a heavy underdog in Stillwater. For a team trying to steady itself this early, the challenge is not just surviving another difficult test, but proving it can keep pace long enough to make the night matter deep into the fourth quarter. [Read more 🡒]

Oklahoma State Faces A Serious Problem Up Front Against Oregon

Oregon arrives in Stillwater with plenty of momentum after handling Boise State and now steps into its first road test of the season against an Oklahoma State team trying to steady itself up front. The Ducks have already shown they can lean on Dante Moore and the passing game, and this matchup offers a chance to see how that balance travels when the crowd gets louder and the game gets more physical.

For the Cowboys, the concern is less about one isolated matchup than the pressure Oregon can apply all over the line of scrimmage. The Ducks pass rush figures to be the first real test for Drew Mestemaker in his latest turn under center, and Oklahoma States recent issues only make the margin for error thinner as it tries to keep the game from tilting early. [Read more 🡒]

Oklahoma State Losses Keep Leading To One Students Wildest Punishments

With Oklahoma States football season producing its share of frustrations, junior Seth Storey has turned the losses into a very public experiment in self-inflicted misery. The Oklahoma State University student built a growing list of personal punishments tied to Cowboys game results, borrowing the idea from something he saw online and adapting it into a series of opponent-specific dares that range from physical challenges to more absurd inconveniences.

Storey has stuck with the concept all season, even after one recent loss sent him into a chicken-tender marathon at a restaurant, part of the kind of punishment he says he intends to follow through on whenever the Cowboys come up short. The whole thing has made for a strange, evolving side plot around the program, with each defeat carrying a different penalty and one looming challenge still hanging out there as the season moves along. [Read more 🡒]