It’s one thing to get clipped in Week 1. It’s another to come back swinging in Week 2 with a fresh set of underdog angles.
The first batch of upset calls didn’t go great - 1-4, with San Jose State at +138 the lone winner - but there’s still plenty to like on the board this week. The slate is full of inflated numbers, shaky quarterback situations, and a few teams that look priced on reputation more than what they’ve shown so far.
Here are five money-underdog picks for Week 2 of the 2026 college football season.
Michigan over Oklahoma
This line has already moved a long way, and that’s exactly why Michigan stands out. Not long ago, the Wolverines were favored.
By the time Week 1 rolled around, Oklahoma had climbed to a small 1.5-point edge at most books. That kind of swing after one game is hard to trust.
There are real concerns about Michigan’s offense against Brent Venables’ defense, and it may not generate much. But Oklahoma doesn’t project as a big-play machine either. The Sooners had trouble getting to 4 yards per carry against UTEP in Week 1, and they’re also dealing with multiple offensive line injuries heading into this matchup.
Oklahoma leaned heavily on two-tight-end sets against the Miners, which suggests a run-first approach. That’s a risky lane to live in when the backfield doesn’t look especially explosive. Lloyd Avant, who ran for 417 yards at Colorado State last season, appears to be the starter.
This one feels like it comes down to a few decisive moments - fourth downs, turnovers, the kind of stuff that can swing a tight game. That makes the current price feel too rich on Oklahoma.
Pick: Michigan to win | 33% on Kalshi | Implied odds: +203
Kansas over Mizzou
Kansas and Mizzou both opened against FCS opponents with new quarterbacks, so there’s still plenty we don’t know. Even so, the Jayhawks are the side I’m willing to trust.
The biggest reason is Andy Kotelnicki. I like the fit of the new offensive coordinator, who’s back in Lawrence after spending the last two seasons at Penn State.
With Kotelnicki running the offense in 2022 and 2023, Kansas averaged about 7 yards per play. That matters.
I also like the early look at Isaiah Marshall, even in a limited sample. He’s thrown for 274 yards and 2 touchdowns on 22 attempts, though those snaps came in low-leverage situations.
There is a strong counterpoint here: Eli Drinkwitz has won 7 straight games as a road favorite and is 6-1 ATS in those spots. Still, I’m taking Kansas because I think the Jayhawks are better than the kind of SEC bottom-feeders Mizzou usually gets priced against on the road.
Pick: Kansas to win | 33% chance on Kalshi | Implied odds: +203
Memphis over Boise State
Boise State’s close loss to Oregon may have earned the Broncos too much credit. That game could say more about Oregon than it does about Boise State, especially with the Ducks playing their first game under two new coordinators. Oregon also didn’t look close to its ceiling in the opener.
The second half told another part of the story. Boise appeared to wear down, and Oregon outgained the Broncos 10.1 to 4.2 per play after halftime. That makes me hesitant to treat Boise as a team that should be heavily rewarded for staying within striking distance.
There’s also the quick turnaround factor. Boise had to spend a lot of energy hanging around in that game for so long, and now it has to reset for a Memphis team that’s rolling after a 2-0 start. That’s not an easy assignment.
Marcus Stokes is another reason Memphis looks live. Through games against UNLV and Arkansas State, the quarterback has posted a completion percentage over expected of 8.8% and an average depth of target of 12.3 yards. He may be the second-best quarterback Boise sees all year behind Dante Moore.
Pick: Memphis to win | 25% on Kalshi | Implied odds: +300
Iowa State over Iowa
I don’t really understand why Iowa is laying 14 points here. That’s a huge number in a rivalry game, especially when Iowa State has enough offensive pieces to make this uncomfortable.
Yes, the Cyclones made a full coaching change this offseason, with Jimmy Rogers replacing Matt Campbell. But there’s a case that Iowa State brings the better passing attack into this matchup.
Jaylen Raynor is an experienced quarterback who threw for more than 3,000 yards last season at Arkansas State, and he’s used to handling a heavy workload. New offensive coordinator Tyler Roehl comes to Ames after time with the Detroit Lions, and before that he called plays for some strong North Dakota State teams, including Trey Lance’s record-breaking 2019 season.
Iowa may have the stronger defense, but the number is simply too high for me to pass on Iowa State.
Pick: Iowa State to win | 17% on Novig | Implied odds: +488
Eastern Michigan over Michigan State
This is the biggest swing of the bunch. Eastern Michigan is a 17.5-point underdog at most shops, and that feels excessive.
Michigan State was only a 9.5-point favorite last week against Toledo, and I’m not convinced Toledo is better than EMU. I’m also not sold on the Pat Fitzgerald experiment in East Lansing.
Even setting aside the controversy, Fitzgerald had clearly lost a step before his Northwestern run ended. In his last three seasons that weren’t heavily affected by the pandemic, he went 3-24 in Big Ten play.
That makes an outright Spartans loss to a mediocre MAC team feel very much in play.
There’s also a personal angle in this matchup: EMU quarterback Noah Kim spent multiple seasons at Michigan State early in his career. He’s grown into a strong Group of 6 quarterback who does a good job of avoiding sacks and negative plays.
Pick: Eastern Michigan to win | 17.5-point dog at most shops
In Other News...
Mizzou Returns To Kansas With A Border War Streak Under Pressure
The Border War has always carried more than football baggage, and this meeting brings that history right back into focus. The rivalry traces its roots to the violent clashes of the 1850s and early 1860s, then grew into a football series that began in 1890 and has now reached its 122nd game. Missouri enters with the upper hand in the series and four straight wins, a reminder that the Tigers have had control of this matchup for a while.
Lawrence, though, has been a tougher stage for Missouri to conquer, which is part of what gives this trip its edge. The Tigers are headed back to Kansas for the first time in years, and while the series lead says one thing, the venue says something else entirely. For Missouri, this is the kind of game where the past is never far away and where the pressure is built into the setting before the ball is even kicked. [Read more 🡒]
Missouri Faces A Border Showdown Twist That Could Decide Everything
The Border Showdown is back on the schedule soon, and this one carries the sort of edge that makes a rivalry feel bigger than its setting. Missouri and Kansas are meeting for the second time since the Tigers joined the SEC, and the game arrives with both sides trying to sort through key injury questions while the matchup itself is headed to Lawrence, where stadium renovations will add another layer of oddity to the scene.
The personnel uncertainty matters because the spotlight is already landing on two inexperienced quarterbacks, Isaiah Marshall for Kansas and Austin Simmons for Missouri, in a game where every mistake can tilt the mood in a hurry. Missouri also enters with questions in the backfield, while Kansas is managing its own concerns on defense and at receiver, leaving plenty of the usual rivalry drama to be decided by which side can patch together enough stability before kickoff. [Read more 🡒]
Mizzou's Run Game Suddenly Has A Problem Tigers Fans Know Well
The Missouri offense spent the first half of its 2026 opener looking out of sync, and the run game was the clearest place where it showed. A year after the ground attack was one of the Tigers strengths, the early returns were a reminder of how quickly that edge can disappear when the line and backfield are not whole.
Ahmad Hardy is still working back from injury, with his return projected for later in September, and the depth chart took another hit when Malae Fonoti went down with a torn ACL. Cayden Green also has been recovering, though help at least appears to be on the way soon, giving Missouri a chance to steady an area that suddenly feels a lot more familiar than the staff would like. [Read more 🡒]