Kyler Murray will not be on the field Monday night when the Vikings meet the Bills, and that absence has already reshaped both the quarterback plan and the betting market.
Murray is out for his second game of the 2026 season because of a Grade 2 hamstring strain. With him sidelined, Carson Wentz is set to make his first start since Week 2. Wentz stepped in for Murray in Week 1 after the former No. 1 overall pick went down with a concussion, and Minnesota rode those early games to wins over Green Bay and Chicago.
Head coach Kevin O’Connell said Murray is week-to-week, which leaves his status for Week 10 very much up in the air. Head Coach Kevin O’Connell announced that Carson Wentz will start Monday. QB Kyler Murray (hamstring) is considered week-to-week.
The quarterback change helped drive plenty of movement on the spread before things settled. The Vikings are now 3.5-point underdogs, after DraftKings Sportsbook had briefly moved them to 2.5-point underdogs at home earlier in the week. Minnesota opened as a three-point underdog on Sunday night, so after all the quarterback chatter, the line ended up back where it started.
Murray’s season numbers show a solid passing line, even if the offense around him has not clicked. He has completed 64.9 percent of his throws for 1,022 yards, five touchdowns and three interceptions, while also adding 29 carries for 167 yards on the ground.
As for the offense itself, it has been one of the league’s least efficient units. Minnesota ranks 30th in EPA/Play and 31st in success rate.
There’s at least a case that Wentz may not be a massive drop-off. He has thrown three touchdowns this season, though he didn’t top 300 total yards in either of his starts against Green Bay and Chicago.
Minnesota enters the week at 6-1 and in control of the NFC North, but a loss to Buffalo would make the NFC playoff race more complicated for O’Connell’s team. If Murray is out for an extended stretch, Wentz would remain the starter unless the Vikings make a trade by Tuesday’s deadline.
Odds refresh periodically and are subject to change.
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