Monday night’s Week 5 finale has the kind of setup bettors love: two teams sitting at the top of the Super Bowl odds, a total north of 50, and plenty of touchdown options on both sides. The Bills and Rams meet in Los Angeles, and the anytime touchdown market looks loaded.
Buffalo comes in with Josh Allen leading an offense that has been one of the league’s most efficient through four weeks, ranking top-three in EPA/Play and yards per play. Los Angeles, meanwhile, has not exactly flown out of the gate on offense, but Matthew Stafford still has a full menu of weapons - Kyren Williams, Puka Nacua and Davante Adams - and the matchup points to scoring.
The Bills’ defense has been a problem early, sitting 29th in EPA/Play through the first four weeks, and that’s a big reason this game has such strong shootout appeal. With that in mind, three names stand out as anytime touchdown scorers.
Allen has scored in every game this season, yet he’s only -115 to find the end zone here, even with other players carrying minus odds. He’s already piled up seven total touchdowns in 2026 and remains one of the safest goal-line bets in football.
His rushing volume dipped in Week 4 - five carries for four yards and a score - but he still has 33 carries on the year and at least five in every game. That kind of usage gives him a sturdy floor, and his touchdown track record backs it up: 12 or more rushing scores in each of his last three completed seasons.
Keon Coleman is the other Bills player worth a look. The former second-round pick hasn’t had a huge NFL career so far, but he just turned in a breakout-type performance in Week 4, catching six passes for 116 yards and his first touchdown of the season against New England.
DJ Moore’s shoulder injury has changed the picture, and Coleman has played more than 74 percent of Buffalo’s offensive snaps in two of his four games. He’s also topped six catches in both games when Moore was sidelined.
In a game that could turn into a track meet, that price is attractive.
On the Rams side, Puka Nacua looks like the cleanest play. After missing two games, he returned in Week 4 and immediately looked like himself, hauling in nine of 12 targets for 125 yards.
He also scored his first touchdown of the season on a two-yard rush. Nacua is averaging 10.5 targets and seven receptions per game, and Stafford is clearly going to lean on him.
The Bills have been vulnerable everywhere in the passing game, ranking in the bottom 10 in passing yards allowed, 29th in EPA Play and 30th in success rate, while also giving up the fourth-most passing touchdowns in the league. At -135, Nacua still fits the profile.
Odds refresh periodically and are subject to change.
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