Tyler Warren’s status is suddenly one of the biggest questions hanging over Colts-Titans in Week 6.
The Indianapolis tight end landed on the injury report Friday with a groin issue after getting hurt in practice, and that leaves him as a game-time decision for Sunday’s AFC South matchup. At this point, there hasn’t been any report suggesting he’s clearly trending in either direction, so the Colts are waiting it out.
Indianapolis did make a move to cover itself, activating tight end Will Mallory from injured reserve on Saturday. Mallory is expected to play against Tennessee, and his return gives the Colts some backup at the position if Warren can’t suit up.
Warren has been a central part of the offense all season. The former first-round pick has hauled in 30 of 36 targets for 213 yards and two touchdowns, and he’s also chipped in on the ground with three carries for six yards and a rushing score.
His workload has been especially steady of late. Warren has caught at least five passes in each of the last four weeks, and he’s been targeted five or more times in all five games in 2026.
With Alec Pierce still out, Warren has become the clear No. 1 option in the passing game, collecting 21 catches in three games since Pierce went down. He was targeted nine times in Week 5 and has played 91.1 percent of the Colts’ offensive snaps through five weeks.
That matters for the betting market, too. The Colts opened as seven-point favorites, but DraftKings Sportsbook has since moved the line to Indianapolis -6.5 at home. Warren’s injury may have played a role in that shift, even though DraftKings says 80 percent of spread bets are still backing the Colts to cover.
If Warren is active, his receptions prop stands out. Tennessee enters the game ranked 28th in the NFL in EPA/Pass, and Warren’s recent usage gives him a strong floor if he’s on the field. Bettors, though, will need to wait for his final designation before making a move.
Odds refresh periodically and are subject to change.
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