The Indianapolis Colts walk into Week 2 with a lot to clean up, and the Kansas City Chiefs come in looking like the steadier, sharper team after opening the season in far better shape.
Indianapolis got little going offensively in Daniel Jones’ return from an Achilles injury, and the defense had a rough day against the Baltimore Ravens. Kansas City, meanwhile, got an efficient outing from Patrick Mahomes and saw its defense overwhelm the Denver Broncos. Add in the fact that the Chiefs are at home and have a roster full of players who’ve been through winning stretches in recent seasons, and it’s easy to see why most of the Week 2 picks lean their way.
BetMGM lists the Chiefs as 6.5-point favorites, with the over/under set at 46.5 total points. On the moneyline, the Colts are +240 and the Chiefs are -295.
The predictions reflect that gap.
Joel A. Erickson of IndyStar went with the Chiefs 38-21, writing, "Indianapolis got off to a terrible start in the season opener, the kind that’s hard to shake off in a single week against a good opponent. Until the Colts prove they can stop anybody defensively, it’s hard to imagine Indianapolis putting up a fight against one of the league’s best quarterbacks."
Nathan Brown of IndyStar also picked Kansas City, taking the Chiefs 35-27. "A week ago, this game very much felt like a toss-up, but after seeing how porous the Colts defense performed, along with how strong all around Kansas City played against the AFC finalists of a year ago, it’s just hard to envision Indianapolis pulling this one out. While I think they could later in the year, this defense is in too much disarray, and I’m not sure the offense is ready yet to win a shootout in primetime on the road against Andy Reid, Patrick Mahomes and company.”
Dan Parr of NFL.com landed on Chiefs 27-17. He pointed to Kansas City’s dominant showing against Denver and Indianapolis’ 41-23 loss to Baltimore, noting that it already feels like “desperate times” for Shane Steichen’s team.
Parr also highlighted the Colts’ defensive issues after Baltimore piled up 202 rushing yards and four rushing TDs, then said he isn’t sure a week is enough time for Lou Anarumo to solve a suddenly dangerous Kansas City ground game led by marquee offseason addition Kenneth Walker III. Jonathan Taylor’s nearly 100 yards and two TDs for Indianapolis weren’t enough last week, and Parr wrote that the Chiefs are better equipped to handle the opponent’s strengths.
Brent Sobleski of Bleacher Report was the lone picker to back the Colts outright. He wrote that Indianapolis was “one of the biggest disappointments” to open the 2026 campaign, while Kansas City was among the most impressive, but still saw the setup as one that “screams of desperation.” Sobleski added that the Colts will get everything they have during "Sunday Night Football."
Mike Florio of Pro Football Talk picked Chiefs 27-10, saying, "The Chiefs are back. The Colts already have their backs to the wall, after an ugly performance to start the season."
Vic Tafur of The Athletic took the Colts to cover the spread. He contrasted the “new-look Chiefs” with the “old-look Colts,” noting Kansas City had 31 designed runs against the Broncos after averaging 21 the previous seven years. Tafur also pointed to the Colts’ struggles in the trenches and said the team’s answer was to move the green dot from safety Cam Bynum to linebacker Akeem Davis-Gaither.
Pete Prisco of CBS Sports went with Chiefs 27-17, writing, "The Chiefs ran it down the Broncos' throats Monday night and will try to do the same to the Colts, who struggled last week against the Ravens. Look for Kenneth Walker III again to key the offense for the Chiefs, but I think the passing game will come alive too. Chiefs take it."
Bill Bender of Sporting News also had Kansas City by 10, 27-17. He noted that the Chiefs stayed home for Week 2, that the Colts struggled in Daniel Jones’ return, and that Jonathan Taylor remains the focal point of the Indianapolis offense. Bender also pointed out that Kansas City beat Indianapolis 23-20 last season before asking, "Is this a trap game?"
Frank Schwab of Yahoo.com took the Colts to cover, calling it a difficult game to sort through. He said Kansas City’s defense looked good and Kenneth Walker III was outstanding against Denver, but added that the passing game still remains an issue. Schwab also said nothing looked good for the Colts in Week 1, which makes them hard to back at Arrowhead Stadium, though “ugly dogs cover all the time in the NFL.”
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