Thursday night brings a Week 2 fantasy spotlight to Buffalo and Detroit, and the prop board is loaded with the kind of names that can swing PrizePicks lineups fast. The Bills and Lions both opened with wins, and several of the biggest Week 1 producers are back in focus for a matchup that should lean on the passing game.
Amon-Ra St. Brown is one of the cleanest touchdown angles on the slate.
He caught both of Jared Goff’s passing scores in last week’s win over the New Orleans Saints, and he’s set up for heavy volume again in a Lions offense that carries momentum into a meeting with a Buffalo defense that struggled against the pass in Week 1. His anytime touchdown prop gives users a multiplier to chase, and the setup points to another strong scoring chance.
Josh Allen also arrives on Thursday night after looking every bit like an MVP candidate in the opener against the Houston Texans. He threw for 334 yards and two touchdowns, then added 23 rushing yards and two more scores on the ground. Against a Lions defense that comes in on a short week, Allen’s dual-threat ability near the goal line makes his anytime touchdown line especially appealing.
DJ Moore wasted no time making an impact in his Bills debut, flashing the kind of upside that makes him such a dangerous fit alongside Allen. He caught five of eight targets for 100 yards and a touchdown in Week 1, and he should stay near the top of Allen’s read list against Detroit. With his receiving line set at 62.5 yards, the volume gives him a strong case, especially with the Lions having allowed 182 yards to Chris Olave in New Orleans’ WR1 role.
Jameson Williams rounds out the group as a player who looks primed for a rebound. He took another step in 2025 with his second straight 1,000-yard season, which raised expectations even higher heading into 2026.
Williams was held in check despite significant volume last week, but he still saw 10 targets and should be in line for another busy night in a game that figures to lean heavily on Detroit’s passing attack. His four-reception prop is one of the favorites on the board for Thursday.
In Other News...
Lions Face A Prime-Time Problem As Jahmyr Gibbs Heads To Buffalo
The Lions are heading into a short week with a little less stability up front than they probably wanted. Detroit visits Buffalo on Thursday night in Week 2, and the matchup comes with both teams sitting at 1-0 after opening wins, the Bills over Houston and the Lions in overtime against New Orleans. It will also be Buffalos home opener at the new Highmark Stadium, with the game set for Prime Video, which gives the stage an early-season feel before either side has much time to settle in.
For Detroit, the bigger concern may be how it handles the trenches without starting left guard Christian Mahogany and right tackle Blake Miller, both out because of injuries. That puts even more attention on a Lions offense that is already expected to lean on Jahmyr Gibbs, especially in a game that could turn physical quickly under the lights in Buffalo. Prime-time road games are one thing when a line is intact, and another when the protection and run-game pieces are already shifting before kickoff. [Read more 🡒]
Lions Could Catch A Break In Buffalo's First Outdoor Test
The Lions are heading into one of the more interesting road setups on their schedule, with Buffalo set to host them at the Bills new Highmark Stadium, a building that still does not have a roof. Forecast rain before kickoff could turn the surface slick and make this as much a test of footing and ball security as it is of talent, which is exactly the kind of wrinkle that can change how both teams script their first few drives.
For Detroit, the weather could tilt the game away from a pure trench battle and toward a more pass-heavy approach if the ground game becomes harder to trust. Wet conditions always raise the stakes on exchanges, cuts and catches, and if the field plays fast but slippery, the Lions may have to lean on cleaner operation through the air while both sides try to avoid the kind of mistakes that rain can manufacture. [Read more 🡒]
Lions Stars Got Snubbed After Putting Detroit In The Spotlight
Week 1 put Detroit in the national spotlight in more ways than one, and the Lions had more than enough star power to earn some leaguewide recognition. Jahmyr Gibbs was electric on the ground for Detroit, piling up 156 yards and two touchdowns, while Aidan Hutchinson kept making his presence felt on defense as the Lions opened the season with a performance that looked every bit like a team built to matter.
The weekly awards, though, went elsewhere. Chicago Bears running back D'Andre Swift was named NFC Offensive Player of the Week over Gibbs after rushing for 124 yards and three touchdowns, and Philadelphia Eagles linebacker Zack Baun took Defensive Player of the Week ahead of Hutchinson. It leaves Detroit with the kind of early-season slight that tends to stick in a locker room, especially when the production was right there for everyone to see. [Read more 🡒]