Lions Get An Early Road Test That Could Say A Lot

Can the Detroit Lions overcome the tough challenge of the Buffalo Bills in their anticipated road game at Highmark Stadium?

The Detroit Lions are heading on the road for the first time in the 2026 season, and the assignment is as big as it gets: a Thursday night trip to Highmark Stadium to face the Buffalo Bills in their home opener at the brand-new stadium.

Dan Campbell didn’t exactly downplay the challenge on Monday. He called Buffalo a “really good opponent” and pointed to the pieces that make this matchup so demanding.

“Obviously, really good opponent. I know Joe Brady very well; that’s a heck of a start there,” Campbell said during Monday’s press conference.

“Can’t say enough about this quarterback; he’s a catalyst for them. This is a good O-line, they got weapons, it’s a good back.

This defensive line is their catalyst over there: Ed Oliver and (Greg) Rousseau, man, really good player, length, explosive. They got Chubb on the other end.

Big boy in the middle, it’s an active defense and it’s a big win for them yesterday. We got our hands full.

They’re aggressive on special teams. It’s opening night out at their place Thursday night; it’ll be electric.

You know, it’s going to be a great atmosphere. We’ll be looking forward to that.

Excellent opponent. This will be a big time game here early in the year.”

The Pride of Detroit staff has also weighed in with its Week 2 picks for the Lions.

For the rest of the POD staff’s NFL predictions, including moneyline, spread, and over/under picks, those will be available Sunday morning.

The bigger question now is simple: can the Lions ruin Buffalo’s opening night in the new stadium, or will the Bills use the moment to show why they’re considered one of the AFC favorites?

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