Bo Nix Gives Broncos Fans Real Hope In Brutal 49ers Test

Bo Nix's remarkable track record against NFC teams may be the key to a crucial Broncos victory as they face a formidable, yet vulnerable, 49ers squad.

Bo Nix and the Broncos have built a strange kind of habit against the NFC, and it gets put back on the line in Week 4.

Denver heads to San Francisco to meet an undefeated 49ers team that has looked sharp on both sides of the ball, even while dealing with plenty of injuries. On paper, this is a tough draw.

The 49ers have been rolling through three weeks, and they’re coming off games against Miami and Arizona. But the Broncos have also shown they can hang in these NFC matchups, and that’s the part that matters most here.

The Nix-led Broncos are 10-1 against the NFC, with 10 straight wins after that lone loss in Nix’s first NFL start against the Seattle Seahawks in the 2024 NFL Season. That run has come with Nix putting up big numbers across 11 games against NFC opponents:

262/405 (64.7 percent)

2,686 yards

21 touchdowns

5 interceptions

95.8 passer rating

268 rushing yards

6 rushing touchdowns

Stretch that production over a full 17-game season, and the pace looks even louder:

405/626

4,151 yards

32 touchdowns

8 interceptions

414 rushing yards

9 rushing touchdowns

That’s a 41-touchdown pace against the NFC so far, and with Denver playing the entire NFC West this year, this is the stretch where that trend has to keep showing up. The NFC West might be the best division in football, which makes this test even more telling.

The 49ers bring a strong statistical profile into the matchup, ranking 2nd in points per game and 3rd in points allowed per game. Still, the Broncos have been close to automatic against NFC teams, and this game fits right into that pattern. Denver has spent well over a year living in close games, and this one feels like it should be no different.

That matters because the AFC playoff race could be tight enough that every win ends up counting. Denver may not get many easy ones, and this trip to San Francisco comes in the middle of the team’s six-game gauntlet to open the season. If the Broncos are going to keep their edge in that kind of schedule, Nix’s NFC dominance needs to be there again in Week 4.

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