The Bills are back home for Week 4, and the betting market is leaning hard toward Buffalo to handle business against New England.
After surviving a tougher-than-expected battle with the winless Los Angeles Chargers, the 3-0 Bills return to the new Highmark Stadium for the final game of a three-game homestand. On the other side, the 1-2 Patriots are trying to steady themselves while their fan base watches a rough start unfold.
The opening number reflected that gap. Buffalo came out as a 6.5-point favorite (-6.5 | -118) at FanDuel Sportsbook, with New England listed at +6.5 (-104). The moneyline sat at -330 for the Bills and +270 for the Patriots, while the total opened at 48.5 (-110).
A lot of the conversation around this matchup has centered on the quarterbacks. Drake Maye is drawing questions about what’s wrong, while Josh Allen’s status has become part of the discussion, too. Allen is now in year three, which means there’s plenty of film on Maye, and Joe Brady doesn’t appear overly concerned about Allen’s condition.
The line also suggests oddsmakers expect Buffalo to clean things up after its shaky outing against the Chargers, while seeing New England as a team still sorting through its issues.
The teams split last season’s meetings, with the home team losing both times. Buffalo won the most recent matchup 35-31 on December 14, 2025.
There are some notable differences between these two teams this season, even if the rivalry still carries plenty of weight. One of the biggest for Bills fans: Stefon Diggs is no longer catching passes for the Patriots.
Buffalo’s injury report will be worth watching this week, especially with Allen and whatever he may or may not be dealing with, as Sunday’s game approaches.
In Other News...
Bills 3-0 Start Now Comes With A Josh Allen Concern
Buffalos perfect start has been built around Josh Allen doing what he always does, which is absorb hits, extend plays and keep the offense moving even when things get messy. So the sight of Allen taking a helmet to the knee in Week 3 was an immediate concern, even if he stayed in the game and the early read is that the issue is a contusion rather than something more severe.
The Bills are moving on to their next matchup with the New England Patriots, but Allens knee will be watched closely as the week unfolds. For a team sitting at 3-0, the larger picture is obvious: the record looks clean, but the health of the quarterback driving it is now part of the story. [Read more 🡒]
Josh Allen Is One Score Away From A Bills Milestone
Buffalos fast start has been fueled by the same familiar engine, with the Bills opening the 2026 season 3-0 and piling up a league-leading 101 points through three weeks. Josh Allen has been right in the middle of it again, and his latest visit to the end zone against the Chargers carried more than just the usual weight of another productive afternoon.
Allens 1-yard rushing touchdown in Week 3 tied him with Thurman Thomas and Andre Reed for the most scrimmage touchdowns in franchise history at 87, a reminder of how much he has already added to the teams record book. He still finished the day with two interceptions, but the Bills keep moving forward with Allen now sitting one score away from standing alone atop one of the franchises most notable milestones. [Read more 🡒]
Bills Win Sparked Ugly Chargers Backlash Around Harbaughs Staff
The Chargers came out of their loss to the Bills carrying plenty of frustration, and not just because the defense forced five turnovers and still watched the offense manage only 10 points. Buffalo's latest win over Los Angeles only deepened the sense that this matchup has become a sore spot for a Chargers team that could not turn mistakes into enough production to stay in control.
Breiden Fehoko turned that frustration public, taking aim at the coaching staff's play-calling on social media, while Jim Harbaugh acknowledged the team's struggles and kept his focus on the collective nature of wins and losses. For Buffalo, the result was another convincing edge in a series that has gone the Bills' way three straight times, but for the Chargers the bigger issue is how quickly the criticism around Harbaugh's staff is starting to spill into the open. [Read more 🡒]