Thursday night brings a heavyweight matchup right out of the gate in NFL Week 2, with the Buffalo Bills and Detroit Lions meeting in the first game at Buffalo’s new stadium.
The Bills opened their season with a road win over the Houston Texans, and Josh Allen was at the center of everything. He accounted for four total scores and threw for 334 yards, while Dalton Kincaid and D.J.
Moore each topped 100 receiving yards. That kind of start makes Buffalo a dangerous home favorite, especially against a Detroit secondary that was pushed around in Week 1.
Detroit escaped with a win over the New Orleans Saints, but it was hardly clean. The Lions gave up more than 400 passing yards to Tyler Shough and needed a stop on a 2-point conversion in overtime to finish the job after scoring 31 points.
That’s the backdrop for a game that has already drawn plenty of betting attention, and SI Betting’s senior editor Iain MacMillan made his stance clear in his Road to 272 column: he’s grabbing the points with Detroit.
“As tempting as it is to back the Bills after how both teams looked in the opening week, I have to do my best not to overreact to a one-game sample size and stick to my belief that the Lions are one of the best teams in the NFL. Their metrics were elite last season, but injuries and poor variance led to them missing the playoffs.
There's no denying that Josh Allen is once again going to be an MVP candidate, but let's not overlook the fact that their defense allowed the Texans to rack up yards and points against them last week. Their defensive roster is completely different from a year ago, so I didn't know what to expect from them this season, but ranking 19th in opponent EPA per play and 22nd in opponent success rate isn't a good start.”
Allen’s passing props are drawing attention for good reason. He just carved up a Texans defense that ranked No. 1 in EPA/Play in 2025, and he did it while landing two 100-yard receivers.
Now he gets a Lions defense missing starting safeties Brian Branch and Kerby Joseph to start the season. Detroit’s Week 1 numbers were ugly, too, as the Saints piled up 410 passing yards.
There is still some risk with Allen’s passing yardage because he averaged 215.8 passing yards per game last season, but Buffalo’s offense has already shown it can hit explosive plays in bunches. With D.J. Moore in the mix, the Bills have more ways to attack a compromised Detroit back end.
There’s also interest on the Detroit side in Sam LaPorta, who drew eight looks in the opener and turned them into five catches for 48 yards. He didn’t score, but the case for him to find the end zone Thursday is straightforward: Buffalo allowed 274 passing yards and two touchdowns to C.J.
Stroud and the Texans, and its pass defense sits 19th in EPA/Pass. Jared Goff has leaned on Amon-Ra St.
Brown in the red zone, but LaPorta’s size and movement make him a tough cover, and he played 62 snaps, or 80.5 percent, in Week 1.
Dalton Kincaid is another tight end getting plenty of attention. He was excellent against Houston, catching five of six targets for 130 yards and repeatedly flashing the big-play ability that has made him such a key piece in Joe Brady’s offense. Kincaid scored five times in just 12 games in 2025, and he was on the field for 72.4 percent of Buffalo’s offensive snaps in Week 1 after spending much of last season below the 50 percent mark.
Detroit also had trouble handling Saints tight end Juwan Johnson late in its opener, which only strengthens the case for Kincaid in this matchup. With both defenses showing cracks through the air, the tight end markets are getting plenty of looks heading into Thursday night.
Odds refresh periodically and are subject to change. If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.
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Bills Fans Get A Wild New Game Day Twist For Lions Opener
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Bills Make A Game Day Choice That Says Plenty Vs Lions
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Dortch brings a little NFL mileage after stints with multiple teams and 12 games already on his 2025 resume, while Gore has been a steady presence on Buffalos practice squad since arriving as an undrafted free agent. The futures contract signaled the Bills wanted to keep him in the building, and this elevation gives him a chance to be part of the conversation in a meaningful spot, even if the bigger picture beyond Sunday is still unfolding. [Read more 🡒]