Roy Lopez’s status could end up shaping a big early test for the Arizona Cardinals.
After Arizona’s Week 1 win over the Los Angeles Chargers, Lopez stood out as the Cardinals’ top performer, according to Pro Football Focus. The interior defensive lineman posted an overall 90.6 grade, which ranks second in the league among interior defensive linemen. His work against the run was especially sharp, as Arizona held the Chargers to 81 rushing yards - the best mark of Lopez’s career.
Now the Cardinals may have to face the Seattle Seahawks without him. Head coach Mike LaFleur said Friday that Lopez is dealing with a groin injury, and he is questionable for the home opener.
Lafleur’s injury update on Lopez:
"Got a little bit of a groin, so we'll see."
Arizona Cardinals coach Mike LaFleur on the status of DL Roy Lopez going in to Week 2 @PHNX_Cardinals pic.twitter.com/6YCMCpZmNL
- Bo Brack (@BoBrack) September 18, 2026
That creates a potential problem for Arizona in Week 2. Seattle ran for 97 yards in its opener against the New England Patriots, but that game got sideways early after the Seahawks fell behind and lost starting quarterback Sam Darnold to injury. With a full week to prepare, their ground game figures to look more dangerous on Sunday, especially with rookie running back Jadarian Price leading the way.
Price, who is 5’11 and 209 pounds, was part of Notre Dame’s one-two punch on the ground with Cardinals rookie Jeremiyah Love. Now the two will see each other again in a game with sole possession of the NFC West on the line. Seattle finished top 10 in rushing yards per game last season, and while losing Kenneth Walker matters, Price’s speed still gives the Seahawks a real edge.
If Lopez can’t go, Arizona will need Walter Nolen to handle a bigger load inside. Without Lopez anchoring the middle, Seattle’s offensive line may only need a small crease for Price to turn the game into a runaway.
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