The Los Angeles Rams have had Arizona’s number ever since Sean McVay took over, and the numbers are hard to ignore. Since 2017, Los Angeles is 16-3 against the Cardinals, including a 15-3 mark in 18 regular-season meetings and a 1-0 record in the postseason.
For Arizona, the results have been rough more often than not. The Cardinals have picked up just one regular-season win over the Rams in each of 2021, 2022 and 2024. Kyler Murray started two of those victories, while Colt McCoy was under center for the one in 2022.
Jacoby Brissett is still chasing his first win against Los Angeles. He has gone 0-2 in two starts against the Rams last season, and Arizona was outscored 82-37 in those games.
The Rams have also stacked up recent dominance in the series, winning three in a row and four of the last five against Arizona. The Cardinals haven’t won on the road against Los Angeles since 2022, and five of the Rams’ last six victories over the Cardinals have come by at least two scores.
Sunday’s matchup also brings a new wrinkle for Arizona coach Mike LaFleur. This will be his first game against the Rams as more than a position coach. LaFleur spent the last three years on McVay’s staff, and when he served as offensive coordinator for the New York Jets, they never faced Los Angeles.
Brissett and LaFleur now get their shot at changing the script. The game at SoFi Stadium is set for 4:05 p.m.
ET, 1:05 p.m. Arizona time.
In Other News...
Cardinals Fans Have Every Reason To Debate This NFL Punishment
The NFL added another point of frustration for a Cardinals team trying to find its footing, fining tight end Elijah Higgins for unnecessary use of the helmet on a play last week. It was a hefty penalty, and one that stood out in a week when the league handed out 23 fines across the NFL. Higgins has been a modest but useful part of Arizonas passing game through the first five weeks, with eight catches for 96 yards and a touchdown.
For Cardinals fans, the debate is less about the dollars and more about where the line gets drawn on contact in a physical league. Higgins fine ranked among the largest in that weeks batch of punishments, which only makes the scrutiny sharper for a player who is still carving out his role in the offense. It leaves Arizona with yet another reminder that even routine-looking plays can carry real consequences long after the whistle blows. [Read more 🡒]
Cardinals Face A Bigger Week 6 Problem Than Just The Rams
The Cardinals have spent the build-up to Week 6 shuffling their roster and trying to keep enough bodies available for a trip to SoFi Stadium, where theyll face the Rams while carrying a four-game losing streak. Several players have already been ruled out or listed as questionable, and the uncertainty has added another layer to a week that already feels pivotal for Arizona as it tries to steady itself and get back on track.
Mike LaFleur said the team is handling those calls on a game-by-game basis, with the focus squarely on putting the best possible group on the field Sunday rather than reacting with sweeping changes. Budda Baker remains one of the more notable names in that mix, while Zaven Collins and Blake Gillikin also did not get the kind of weekend bump the Cardinals were hoping for, leaving Arizona with a few lingering questions as kickoff approaches. [Read more 🡒]
Cardinals Fans Know What Makes This Rams Matchup Feel Different
The Week 6 meeting with the Rams carries a little extra edge for the Cardinals, even if both sideline leaders are trying to keep the spotlight on the matchup itself. Arizona head coach Mike LaFleur is preparing to see Sean McVay from the other side for the first time since working on his staff, which adds a layer of familiarity to a game that already has plenty of familiarity built in.
For Cardinals fans, though, the bigger backdrop is the recent history in this rivalry. Los Angeles has owned the series for years, and Arizona has spent plenty of Sundays trying to flip that script. With LaFleur now leading the Cardinals and McVay still setting the tone in Los Angeles, this one feels a little more personal than your usual NFC West game. [Read more 🡒]